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Colonel Autumn, despite being the Final Boss, can be killed with one clean critical to the head, and the two bodyguards nearby are just the same Enclave troopers you've been gunning down all game. Furthermore, Eden's self-destruction code is in Autumn's office, not exactly well hidden either.
And if your Science skill is high enough, you don't even have to attempt those. The argument you make isn't even particularly impressive and basically amounts to pointing out that since he was built by humans, his decisions can't be trusted and he should destroy himself and the Enclave.
You can convince President Eden to kill himself with just two mid-level Speech checks. Does Charon's contract actually allow him to rebel against the Lone Wanderer if hes attacked and refuse to activate Project Purity (if Broken Steel is not installed) or is he actually able to somewhat resist his brainwashing when hes pushed past his limits?. Are those "rivals" as bad as Calvert, or are they actual good people? While he is technically the good guy in Point Lookout storyline ( he doesn't turn against you if you side with him during the quest, while Calvert does if you betray Desmond), it's never clear whereas he is merely an incredibly rude Good Is Not Nice character, or a Villain of Another Story: if he is still alive after you kill Calvert, he states he'll then go after other rivals of him, with no other details.
We don't learn much about Desmond Lockheart's goals, beside he is chasing his old nemesis Calvert and is looking for data in Calvert's lab. The Lyons Chapter of the Brotherhood of Steel gets this from a lot of fans given the traditionalist fans support of the Outcasts. Vance: an altruistic man who uses old legends to motivate cannibals to reform and gives them new lives free from persecution, or a delusional nutcase who brainwashes people to forcibly conscript them into his "Family"?. imply he really does feel bad about what he's doing, but also that he's proud of what he's doing in the name of progress. Is Ashur really a Well-Intentioned Extremist who wants to try and use the Pitt to make a better future for its people, or is he just as evil as his Raider minions and trying to rationalize his actions by claiming that they're Necessarily Evil? Script notes in the G.E.C.K.